منابع مشابه
Parvin-ILK
Integrin-linked kinase (ILK), PINCH and Parvin proteins form the IPP-complex that has been established as a core component of the integrin-actin link. Our recent genetic studies on Drosophila parvin, reveal that loss of function mutant defects phenocopy those observed upon loss of ILK or PINCH in the muscle and the wing, strengthening the notion that these proteins function together in the orga...
متن کاملThe Integrin‐Mediated ILK‐Parvin‐αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells
Epithelial cell adhesion to the surrounding extracellular matrix is necessary for their proper behavior and function. During pregnancy and lactation, mammary epithelial cells (MECs) receive signals from their interaction with laminin via β1-integrin (β1-itg) to establish apico-basal polarity and to differentiate in response to prolactin. Downstream of β1-itg, the scaffold protein Integrin Linke...
متن کاملThe ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
Dynamic interactions of cells with their environment regulate multiple aspects of tissue morphogenesis and function. Integrins are the major class of cell surface receptors that recognize and bind extracellular matrix proteins, resulting in the engagement and organization of the cytoskeleton as well as activation of signalling pathways to regulate cell behaviour and morphogenetic processes. The...
متن کاملNephrin phosphorylation regulates podocyte adhesion through the PINCH-1-ILK-α-parvin complex
Nephrin, a structural molecule, is also a signaling molecule after phosphorylation. Inhibition of nephrin phosphorylation is correlated with podocyte injury. The PINCH-1-ILK-α-parvin (PIP) complex plays a crucial role in cell adhesion and cytoskeleton formation. We hypothesized that nephrin phosphorylation influenced cytoskeleton and cell adhesion in podocytes by regulating the PIP complex. The...
متن کاملFunctional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
Visualization and quantification of the dynamics of protein-protein interactions in living cells can be used to explore the macromolecular events involved in signal transduction processes. In this study, functional molecular imaging using a luciferase-based complementation method demonstrated how the integrin-linked kinase (ILK)-mediated protein complex controls downstream signals. The lucifera...
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ژورنال
عنوان ژورنال: BioArchitecture
سال: 2012
ISSN: 1949-0992,1949-100X
DOI: 10.4161/bioa.20700